Two sample MR report
SHTN1_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 9 | 0.1457727 | 0.1301240 | 0.2995618 |
| Weighted median | 9 | 0.0611853 | 0.0121835 | 0.0000005 |
| Inverse variance weighted | 9 | 0.0515871 | 0.0153532 | 0.0007793 |
| Simple mode | 9 | 0.0713343 | 0.0145689 | 0.0011993 |
| Weighted mode | 9 | 0.0645884 | 0.0149108 | 0.0025064 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 22.86590 | 7 | 0.0017987 |
| Inverse variance weighted | 24.60296 | 8 | 0.0018145 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0520261 | 0.0713443 | 0.4895387 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002376 | 1e-07 | TRUE | 0.1489236 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
